Defeat the Alchemical Mutant

Escape the Kraken

Destroy the Rock Blenders in Storage

Escape the Spectral Doppelgangers

Destroy the Demonic Pinwheel

Defeat the Giant Cave Crawlers

Defeat the Stone Giant

Escape the Death Dungeon

Defeat the Vyle Daemon Ambush

Defeat the Watcher

Defeat the Demon Lord

Defeat (?) What Lurks Beneath

Collect a total of 50000 treasure during a single run

Have a rune in every rune slot during a run

Reach tier 4 in Amplified aspect boons during a run

Reach tier 4 in Death aspect boons during a run

Reach tier 4 in Elemental aspect boons during a run

Reach tier 4 in Light aspect boons during a run

Reach tier 4 in Weapon aspect boons during a run

Reach tier 4 in Wealth aspect boons during a run

Reach tier 4 in Movement aspect boons during a run

Reach tier 4 in Health aspect boons during a run

Reach tier 4 in Inventory aspect boons during a run

Unlock 2 tier 4 aspect boons in one run

Raise your maximum health to 14 ale kegs during a run

Raise your maximum mana to 300 during a run

Kill 100 enemies in one level

Take 400 damage during a single run

Have 4 "spell" mana weapons during a run

Have 1,000 ammo for the Crystal Scatter Gun

Have the Flare Gun and Flame Globber at the same time

Have the Acid RPG and Acid Spewer at the same time

Have the Shock Bolt and Lightning Gun at the same time

Find your way out of the looted treasure room

Overcome the redoubt

Defeat the Gorgons

Suppress the swarms

Defeat the insane wizard

Defeat the giant spider

Defeat the drake

Complete Depth 12 without applying any runes

Complete Depth 12 without ever having a scatter gun in your inventory

Defeat What Lurks Beneath 6 times in a single save slot without dying